Department of Biochemistry and Molecular Biology

Meet our Faculty Members

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Faculty Member	Research Interests
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Bastia, Deepak	Analyses of (1) the mechanisms of initiation of DNA replication of prokaryotic plasmids and (2) the termination of DNA replication of plasmid, bacterial and yeast chromosomal, and human mitochondrial DNA
Bielawska, Alicja	Role of sphingolipids in signal transduction and cell regulation with emphasis on cancer biology. Specific interest is related to the regulatory function of ceramide and sphingosine-1-phosphate. Development of molecular and analytical tools to study mechanism of biological action of sphingolipids in relation to their physicochemical properties.
Bielawski, Jacek	Sphingolipids in Signal Transduction Cell Regulation in Cancer Biology Development of new analytical protocols
Bullesbach, Erika	Hormones of Insulin-Like Structure: Chemical Syntheses and Structure-Function Relations
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Chao, Julie	Serine Proteinase Structure-Function Relationship; Purification, Molecular Cloning, Expression, and Function of Proteinases and Proteinase Inhibitors; Serpin Regulation of Gene Expression
Chao, Lee	Nucleic Acid Biochemistry; Regulatory Mechanism in Gene Expression; Gene Therapy in Cardiovascular Diseases
Cowart, Ashley	Regulation of sphingolipid synthesis in obesity, diabetes, and cardiovascular disease. Approaches used include microarrays, lipidomics, mouse models, tissue culture.
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Davies, Christopher	Using X-ray crystallography to determine the structures of medically and biologically important macromolecules
Del Poeta, Maurizio	Role and Regulation of inositol-phosphoryl-ceramide synthase (Ipc1) in pathogenic fungi Role and Regulation of enzymes involved in the degradation of sphingolipids
Duggan, Brendan M	Biological function at the molecular level biophysical techniques such as NMR, ITC and CD to characterize the three dimensional structure and internal dynamics of biomolecules
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Fernandes, Daniel	Molecular mechanisms of drug-induced gene amplification Interactions of anticancer drugs with nuclear matrix proteins, especially DNA topoisomerase II
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Hama, Hiroko	Role of FA2H in myelination and glial cell signaling Role of hydroxy sphingolipids in cell differentiation Development of lipid therapeutics for FA2H deficiency

Hannun, Yusuf	Role and Regulation of Protein Kinase C Isoenzymes Sphingomyelin Turnover and Cellular Regulation The Sphingomyelin/Ceramide Cycle as a Novel Target for Apoptosis and Inflammatory Disease Interventions Ceramide Activated Protein Phosphatases
Heise, Tilman	RNA-binding proteins regulating the posttranscriptional control of gene expression. Our work is centered on the functional analysis of aberrant expressed RNA-binding proteins in cancer pathogenesis.

Hennig, Mirko	Structural Studies of RNA-ligand complexes using NMR Spectroscopy

Hsu, Yi-Te	Molecular mechanisms of apoptosis Bcl-2, Bcl-X_L
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Krupenko, Natalia	Folate and Methyl Group Metabolism Glycine N-Methyltransferase (GNMT)
Krupenko, Sergey	Protein Structure and Function Enzyme Mechanisms and Regulation Folate Metabolism and Carcinogenesis
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Lemasters, John J	Cellular and molecular mechanisms of apoptosis and necrosis; organ preservation for transplantation surgery; mitochondrial physiology and pathophysiology, including mitochondrial permeability transition, mitophagy and calcium homeostasis; oxidative stress; ischemia/reperfusion; confocal and multiphoton microscopy of living cells.
Luberto, Chiara	The role of mammalian sphingomyelin synthases (SMS1 and SMS2) in regulating the metabolic interconnection between sphingolipids and glycerolipids and their functions as potential mediators of cancer pathogenesis.
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Mohanty, Bidyut	Genome integrity. DNA replication arrest-dependent homologous recombination
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Ogretmen, Besim	Roles of sphingolipid metabolism in cancer pathogenesis, chemotherapy-induced cell death, and drug resistance
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Schwabe, Christian	Protein Chemistry; Biochemical Evolution; Chemical Endocrinology

Sommer, Gunhild


Spicer, Eleanor	Post Transcriptional Regulation of Bcl-2 Gene Expression; Regulation of human oncostatin M expression; mRNA stability
Stillway, Bill	Medical education; Lipid metabolism
Szulc, Zdzislaw	Chemical etiology of sphingolipids structure and functions
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Zhang, Yong-Mei	Bacterial quorum sensing network Pseudomonas aeruginosa motility Structures and functions of essential enzymes of bacterial pathogens

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